Learn how to identify and treat Lamictal rash from medication use. It's important to act swiftly to manage the skin reactions and prevent complications. Lamotrigine (Lamictal) is a medication that’s used to treat epilepsy, bipolar disorder, neuropathic pain, and depression. Some people develop a rash while taking it. For some Lamictal patients, hypersensitivity to the drug can cause a serious rash that leads to painful blisters, peeling skin, and hospitalization. A dangerous Lamictal rash looks and behaves differently in several key ways. It tends to start on the trunk and spread outward toward the arms, legs, and face. It may involve the palms of your hands or the soles of your feet. The rash itself may turn from red to a deeper purple color, and painful blisters can form on the skin surface. Lamotrigine Rash: Immediate Management Stop lamotrigine immediately at the first sign of any rash—this is the single most critical action to prevent progression to life-threatening Stevens-Johnson syndrome or toxic epidermal necrolysis. 1 Rashes are a common side effect of the epilepsy drug lamotrigine. Find out what’s normal, warning signs to look out for, and complications. Lamictal rash is a side effect of the prescription medication. This guide discusses symptoms of the rash, as well as information about treatment and diagnosis. Lamotrigine can cause a rash, which may range from mild to serious. Learn how to identify symptoms, reduce risks, and when to seek medical help. Is it better to take lamotrigine at night? If you are taking lamotrigine how long does it take to get out of your system? Is a rash with lamotrigine common? Benign (non-serious) rashes are also caused by lamotrigine. Rashes are listed as a common side effect (occurring greater than 5% to 10% of the time) in the product labeling. Learn how to spot a mild lamotrigine rash versus a serious reaction, and know when to call your doctor right away.